Communication through gap junctions also regulates ameloblast differentiation and bone formation, as a mutation in the gene encoding Connexin 43 has been reported to result in development of oculodentodigital dysplasia, a predominantly autosomal disease characterized by syndactyle, microdontia, enamel hypoplasia, and craniofacial abnormalities [39, 40]. Here, GJA1 is linked to oculodentodigital dysplasia.