Patients without these autoimmune diseases, but with positive aCL antibodies, have shown to have a higher rate of restenosis after PCI showing a direct association of restenosis with these antibodies.26 Nevertheless, a study by Sharma et al27 failed to demonstrate any significant correlation between the level of IgG aCL antibodies and in-stent restenosis after PCI. The gene discussed is ACLY; the disease is autoimmune disease.