IFNG and B-cell chronic lymphocytic leukemia: First, the +874 position, which is in strong linkage disequilibrium with the 12 CA repeat microsatellite in the noncoding region of the 1st intron of IFN-γ gene, controls the production of IFN-γ.20 As we known now, IFN-γ is a proinflammatory cytokine playing a pivotal role in both innate and adaptive immune responses, and has antitumor and antiproliferative effects.6 Therefore, it is understandable that T allele, which with high level IFN-γ production, may be a protect gene for CLL.