Yet a recent meta-analysis showed no association between IFN-γ +874T/A polymorphism and cancer susceptibility,40 at the same time, the other meta-analysis found positive association in cervical cancer and breast cancer,23,26 which suggested that IFN-γ +874T/A polymorphism play different roles in different cancer types; therefore, the conclusion from a pooled analysis for association between IFN-γ +874T/A polymorphism and all cancer types may be unreliable. This evidence concerns the gene IFNG and cancer.