The huge review performed by Paracchini et al23 in 2005 regarding the 3 polymorphisms in the LEPR gene (K109R, Q223R, K656N) and the 2 polymorphisms in the PPARG gene (C161T and P12A) in healthy and obese subjects suggested no evidence of an association between the genes involved in leptin regulation and obesity. The gene discussed is LEP; the disease is obesity disorder.