LEPR and obesity due to melanocortin 4 receptor deficiency: For the LEPR 1019 gene polymorphism we noticed that there was 2.0 higher risk for obesity development in patients harboring the GA+AA genotype in comparison with the control group (OR 2.0; 95% CI 1.11–3.58; P = 0.01), but we did not find a statistical difference or a higher risk of obesity by comparing children with A allele versus children with G allele (P = 0.13).