LEPR and obesity due to melanocortin 4 receptor deficiency: An Asian study performed on 136 Japanese obese children reported that LEPR Lys109Arg and Ser343Ser gene polymorphisms were associated with the degree of obesity, without identifying a correlation with LEPR 223 gene polymorphisms.52 Similar results reported the study of Pyrzak et al33 performed on 101 children, where on 60 obese patients the authors highlighted the association between LEPR 223 gene polymorphism and obesity.