The review of Bender et al21 did not underline an association between the combined LEPR Q223R, K109R, and K656N single nucleotide polymorphism and obesity-related outcomes, but for the LEPR Q223R polymorphism an association with overweight in studies considering a BMI cut-off value of 25 to separate normal weight from overweight was observed. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.