LEPR and obesity due to melanocortin 4 receptor deficiency: In case of the LEPR 223, polymorphism comparing the combination AG+GG with the AA genotype, we observed that there was 3.06 higher risk for developing obesity in variant AG+GG genotype patients (OR 3.06; 95% CI 1.70–5.51; P = 0.0001) and a 1.67 higher probability for G allele carriers (OR 1.67; 95% CI 1.18–2.36; P = 0.0038) for developing obesity, comparative to the control group.