We further demonstrated that the increase in the integrin β3 level in several metastatic cancers with low E-cadherin expression, an indicator of loss of epithelial features [27] (Figure 5A), directed the adhesive signal toward the FAK and Akt signaling, which in turn affected Snail protein stability in TD cells (Figure 5). The gene discussed is PTK2; the disease is metastatic malignant neoplasm.