We further demonstrated that the increase in the integrin β3 level in several metastatic cancers with low E-cadherin expression, an indicator of loss of epithelial features [27] (Figure 5A), directed the adhesive signal toward the FAK and Akt signaling, which in turn affected Snail protein stability in TD cells (Figure 5). Here, SNAI1 is linked to metastatic malignant neoplasm.