AKT1 and malignant colon neoplasm: In colon cancer, ALDH1B1 is dramatically upregulated [29], and by up-regulating Wnt/β-Catenin, Notch and PI3K/Akt signaling pathways, ALDH1B1 can promote colon cancer tumorigenesis, providing a novel target to prevent or treat colon cancer [30].