GC affect more male than female, so we analyzed the survival in different gender (Supplementary Figure S2) and found that these results were independent of gender, supporting that ALDH1A2, ALDH1A3 and ALDH1L1 were the main contributors for ALDH1 activities in GC and potential prognostic markers and treated targets for GC. This evidence concerns the gene ALDH1L1 and gastric cancer.