SOX2 and colorectal cancer: Notably, miR-371-5p is also overexpressed in colorectal cancer and down-regulated SOX2 expression, showing that Recently, SOX2 was identified as a target gene inhibited by miR-371-5p; in this manner, miR-371-5p promotes cell proliferation, invasion, and epithelial-mesenchymal transition in colorectal cancer (CRC) [26].