CLK1 and neoplasm: To further investigate the functional consequence of CLK1-dependent AS, we selected two examples in genes that have important roles in the cell cycle: checkpoint kinase 2 (CHEK2), a tumor suppressor that controls the cellular response to DNA damage and cell cycle entry (Paronetto et al., 2011; Staalesen et al., 2004), and centromere-associated protein E (CENPE), a kinetochore-associated motor protein that functions in chromosome alignment and segregation during mitosis (Kim et al., 2008).