PFKFB3 and celiac disease: One SNP (rs117139146) located in the intragenic region of chromosome 10p15 encoding for PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) was initially identified as being associated with celiac disease through the 1000 Genomes Project using the ImmunoChip in 2012 [8].