TNF and neoplasm: Increased TNFα in the tumor microenvironment induces tumor apoptosis and necroptosis in an autocrine manner; 2) radiation-activated canonical NF-κB p65/p50 and p50/p50 complexes activate Fas expression to increase tumor cells to apoptosis induction by FasL of tumor-infiltrating Tc1 cells [5, 57, 62]; 3) radiation-activated NF-κB also up-regulates CCL2 and CCL5 in tumor cells to attract activated T cell infiltration to the tumor microenvironment; and 4) radiation activates the STING pathway to induce T cell activation.