CD8A and infection: Using DGKαKO and DGKζKO mice carrying the OT1 TCR transgene, which encodes a TCR-recognizing ovalbumin peptide257-264 (SIINFEKL) presented by H2Kb and thus directing T cell development to the CD8 lineage [30], we also found that a deficiency of either DGKα or ζ caused enhanced expansion of OT1 T cells following infection with LM-OVA (data not shown).