Fig 8A shows that CTNNB1 siRNA significantly reduced the β-catenin expression compared with control siRNA. Silencing of the components of the Wnt/β-catenin pathway is known to increase the radiosensitivity of cancer cells. As expected, the knockdown of β-catenin by CTNNB1 siRNA significantly enhanced the radiosensitivity of H1299 cells, whereas transfection with control siRNA did not change the radiosensitivity when compared to 6 Gy radiation alone, as shown in Fig 8B. The gene discussed is CTNNB1; the disease is cancer.