BIN1 and colorectal carcinoma: In this context, it is noteworthy that the α6Bβ4 integrin, the other form of α6β4 that is not increased in CRC cells [6, 7], was found to inhibit CRC cell proliferation and MYC activity, an effect that was explained by the fact that the α6B subunit tail can bind to the MYC inhibitor protein bridging integrator-1 (BIN1) [7] (Step 6).