Looking to the future, it will be extremely interesting to synthesize themes from previous chaperone and disaggregase engineering studies and apply them to re-engineering the TRiC chaperonin (Lopez et al., 2015) or the metazoan protein disaggregase system: Hsp110, Hsp70, and Hsp40 (Torrente and Shorter, 2013; Finka et al., 2015; Nillegoda and Bukau, 2015) to more effectively target detrimental misfolding events connected to neurodegenerative disease. This evidence concerns the gene DNAJB1 and neurodegenerative disease.