The SOD1(G93A) transgenic mouse model for ALS that also harbors a knockout of 1 mSmn allele (SOD1(G93A)+∕−;mSmn+∕−) exhibits a more severe ALS phenotype than SOD1(G93A) ALS mice (SOD1(G93A)+∕−;mSmn+∕+) (Turner et al., 2009). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.