Moreover, in 20% of acute myeloid leukemia (AML) (5, 6), 50% of chondrosarcoma (7, 8), 20% of intrahepatic cholangiocarcinoma (9), and 20% of angioimmunoblastic T-cell lymphoma, IDH1 or IDH2 are mutated as well (10). This evidence concerns the gene IDH2 and chondrosarcoma.