WT1 and neuroblastoma: To characterize the functional role of WT1 isoforms in trans-differentiation of NB cells, their expression profile has been correlated to two different signaling pathways, critically involved in this malignancy, namely, phosphoinositide 3 kinase (PI3K) /Akt and mammalian mitogen activated protein kinase/Erk kinase (MAPK/ERK) signaling pathways.