The UBE4B gene is located in chromosome 1p36.22, a commonly deleted chromosomal region in neuroblastoma tumors, and our results demonstrate an association of UBE4B gene and protein expression with neuroblastoma patient outcomes and prognostic features and of UBE4B protein levels with neuroblastoma tumor cell differentiation, suggesting a role for UBE4B as a novel tumor suppressor gene. The gene discussed is UBE4B; the disease is neoplasm.