HES2 and neuroblastoma: In two separate datasets, UBE4B gene expression was significantly lower in the tumors from patients with chromosome 1p36 deletion, compared to those with wild-type chromosome 1p36, while the expression of three other genes located in the adjacent 1p36 region (TP73, HES2, and AJAP1) was unchanged (Figure 4), suggesting additional mechanisms of regulation of UBE4B gene expression are involved in neuroblastoma tumors.