In institutional tumor samples, reduction of UBE4B protein expression was only seen in poorly differentiated or undifferentiated neuroblastoma tumors or the poorly differentiated component of intermixed ganglioneuroblastomas, and UBE4B protein expression was significantly associated with neuroblastoma tumor differentiation in the cohort of samples (p < 0.0001; Figure 5). The gene discussed is UBE4B; the disease is neoplasm.