(43)] and participate in leukemic physiology, including alterations in the microRNAs repertoire (44), the heat shock stress pathway (45), which can induce MICA and MICB gene expression, or the activation of the PI3K pathway that is often constitutively activated in leukemia (46) and can stimulate the expression of the mouse NKG2D-L RAE-1. Here, MICB is linked to leukemia.