Finally, a new paradigm is taking form in our understanding of the connection between aging and leukemia with the identification of recurrent mutations in genes involved in the epigenetic regulation of the HSCs genome (DNMT3A, TET2, and ASXL1), acquired with age in healthy HSC, and leading to clonal hematopoiesis associated with increases in the risk of hematological cancer, including AML (18–20). Here, DNMT3A is linked to acute myeloid leukemia.