We also aim to carry out further experiments to elucidate the mechanisms, investigating the types of Tregs responsible (e.g., Tr1 and FOXA1+ cells), and are planning to investigate whether H. pylori exerts a long-lasting influence on the Treg and IL-10 response from early life, or if the immunological effects require continual life-long presence of the infection in the gastric mucosa. The gene discussed is IL10; the disease is infection.