A similar mechanism of immune escape has been evolved by arterivirus and nairovirus which express ovarian tumor domain-containing deubiquitinases targeting RIG-I (Frias-Staheli et al., 2007; van Kasteren et al., 2012), and by hepatitis E virus which expresses the ORF1 protein bearing a papain-like cystein protease domain responsible for RIG-I deubiquitination (Nan et al., 2014). This evidence concerns the gene RIGI and ovarian neoplasm.