Also, Lan et al. discussed about the association of Apolipoprotein L1 (APOL1) variants (G1 and G2 alleles) in Heroin-associated Nephropathy (HAN) and Human Immunodeficiency Virus associated Nephropathy (HIVAN) in African Americans which opens an interesting point to explore the onset of focal and segmental glomerulosclerosis (FSGS) in HIV infected heroin abusers in African Americans. The gene discussed is APOL1; the disease is focal segmental glomerulosclerosis.