The controversy about the role of cholesterol in AD remains unsolved, however, we have recently postulated a reconciling hypothesis according to which it is the balance between cholesterol and DHA in lipid raft (which affect membrane viscosity of opposite ways), rather than their individual contents, what mostly affect the physicochemical and thermodynamic properties of these domains, eventually impacting the rate of amyloidogenic processing of APP (Díaz et al., 2015). Here, APP is linked to Alzheimer disease.