In this work we present, the first attempt to quantify the evolution of lipid rafts in Alzheimer's disease by means an agent based mathematical model supported by in vivo lipid data composition of nerve cell membranes and their integrated domains, namely lipid rafts and non-raft domains in Wild-type and APP/PS1 transgenic mice at 3, 6, 9, and 14 months. This evidence concerns the gene APP and Alzheimer disease.