APP and Alzheimer disease: Interestingly, the prediction that lipid rafts sizes increase prematurely might be extrapolated to human AD patients at early stages of the disease, where not only alterations in the lipid matrix and biophysical properties occur (Díaz et al., 2015), but also the accumulation of APP and γ- and β-secretases as well as their association are increased (Fabelo et al., 2014).