Furthermore, immunofluorescence analysis shows a reduction of immunoreactivity for Kv4.2, Kv4.3, and Kv1.5 protein, in isolated ventricular cardiomyocytes from T1DM models vs. healthy controls, and no changes of Kv2.1 (IKr determining protein) were found (Torres-Jacome et al., 2013). The gene discussed is KCND2; the disease is type 1 diabetes mellitus.