FMO5 and ischemia: Numerous subsequent studies have confirmed this finding in focal and global models (Chen et al., 2009; Jackman et al., 2009b; Brait et al., 2010; De Silva et al., 2011; Yoshioka et al., 2011), and have also shown a role for Nox2-NADPH oxidase in ischemia-induced BBB disruption, and dysfunction of larger pial arteries upstream of the BBB (Kahles et al., 2007; De Silva et al., 2011).