DDR1 and central nervous system cancer: Moreover, accumulating evidence using Matrigel or type I collagen as matrix barriers suggests that DDR1 plays a promoting role in invasion of a variety of human cancers including glioma (Ram et al., 2006), hepatocellular (Park et al., 2007), squamous epidermoid (Hidalgo-Carcedo et al., 2011), colorectal (Hu et al., 2014), lung (Yang et al., 2010; Miao et al., 2013; Juin et al., 2014), prostate (Shimada et al., 2008), breast carcinomas (Castro-Sanchez et al., 2011; Juin et al., 2014).