In vitro investigations revealed that these compounds potently inhibited the proliferation of cancer cell lines expressing high levels of DDR1, including A549 and NCI-H23 lung carcinoma, MDA-MB-435, MCF-7, and T47D breast carcinoma and HCT116 colon carcinoma cells (Gao et al., 2013). This evidence concerns the gene DDR1 and breast carcinoma.