C9orf72 and frontotemporal dementia: In the frontotemporal dementias, anosognosia and lack of self-knowledge are underpinned by disintegration of predominantly anterior fronto-insular ‘salience’ and temporal ‘appraisal’ networks (Sollberger et al., 2014) while body schema deficits in association with C9orf72 mutations may be more specifically attributable to dysfunction of a cortico-thalamo-cerebellar network (Mahoney et al., 2012; Downey et al., 2014).