Examining TrkB receptor expression in a well-characterized transgenic mhtt model and further characterizing BDNF functional activation of TrkB signaling in primary striatal cultures derived from the same model may better define which defects occur in the BDNF-TrkB pathway and how this affects neurotrophic support of MSNs at early disease stages of HD. This evidence concerns the gene NTRK2 and Huntington disease.