Low BDNF protein levels are reported in postmortem striatal tissue from HD patients at symptomatic disease stages (Ferrer et al., 2000; Zuccato et al., 2008), however, it is not clear whether this is associated with early neurtrophic deficiencies for MSNs or, rather, a consequence of late stage cortical and striatal neuron atrophy. Here, BDNF is linked to Huntington disease.