CHRNA7 and Alzheimer disease: Previously, we found that regular injections of bacterial lipopolysaccharide (LPS) decreased the density of α7 nAChRs in the brain and brain mitochondria of mice and reduced nucleated cell numbers in the hippocampus and striatum, while stimulating astrocytosis, accumulation of Aβ (1–42) peptides and episodic memory decline—symptoms characteristic of the early stages of AD (Lykhmus et al., 2015).