As such, developing small molecules to decrease LRRK2 GTP-binding and/or stimulate LRRK2 GTPase activity seems a promising strategy for the development of PD modifying treatments and has already shown some encouraging results in LRRK2 GTP and kinase domain mutant PD models (Li et al., 2014, 2015). The gene discussed is LRRK2; the disease is Parkinson disease.