Intriguingly, this effect of LRRK2 is weakened by PD-causing mutations in three distinct catalytic domains of LRRK2 – R1441C in the Roc domain, Y1699C in the COR domain, and G2019S in the kinase domain (Berwick and Harvey, 2012) – suggesting that impaired Wnt signaling is a common pathogenic mechanism of familial LRRK2 mutations. Here, LRRK2 is linked to Parkinson disease.