PPARA and Parkinson disease: Although, PPARα may be a potential therapeutic target in neurodegenerative, neuroinflammatory and neurocognitive alterations related to Alzheimer and Parkinson's diseases (Plaza-Zabala et al., 2010; Scuderi et al., 2012; Fidaleo et al., 2014; González-Aparicio et al., 2014), the involvement of PPARα in age-related decline and environmental enrichment-induced enhancement of adult neurogenesis is still uncertain.