Overall, PPARα activation by endogenous (OEA and palmitoylethanolamide) and/or exogenous (fenofibrate) agonists shows a neuroprotective role by increasing brain cell proliferation and improving neuronal survival associated with spatial long-term memory after different cerebral insults such as whole-brain irradiation, cerebral ischemia, and Alzheimer disease (Ramanan et al., 2009; Scuderi et al., 2012; Yang et al., 2015). This evidence concerns the gene PPARA and early-onset autosomal dominant Alzheimer disease.