Analysis of ∼9,200 nonsynonymous sequence variants revealed a common missense substitution (rs738409, I148M) in PNPLA3 that is associated with the full spectrum of NAFLD, including liver fat content, steatohepatitis, cirrhosis, and hepatocellular carcinoma (5, –, 9). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.