IHC on clinical specimens from CMUH indicated that SCEL was expressed in 81.0% (17/21 cases) of CRC specimens with lymph node metastasis and in 82.4% (14/17 cases) of CRC specimens with hepatic metastasis (Figure 4B), consistent with the previous finding that SCEL expression correlated with cancer malignancy. The gene discussed is SCEL; the disease is metastatic malignant neoplasm in the lymph nodes.