TNF-related apoptosis-inducing ligand or Apo2L (Apo2L/TRAIL), a member of the TNF family expressed mainly by cells of the immune system, is able to trigger ‘extrinsic and intrinsic apoptosis’ that specifically kill tumor cells, rendering it an anti-tumor agent of great value [4]. The gene discussed is TNFSF10; the disease is neoplasm.