PLAG1 and B-cell chronic lymphocytic leukemia: PLAG1 is generally considered as an oncogene in multiple human tumors, such as lipoblastoma [34], hepatoblastoma [35, 36], chronic lymphocytic leukemia [23], acute myeloid leukemia [37], etc. It has been proved to be the direct target of miR-424 based on the luciferase reporter assays and its overexpression was putatively involved in CLL pathogenesis [23].