Several mechanisms involved in AML TRAIL resistance have been outlined, such as decreased expression of DR4 and DR5, increased expression of DcR1 and 2 which are unable to evoke apoptosis upon TRAIL binding, upregulaion of cFLIP that blocks the recruitment of Caspase8 to DISC, accumulation of Mcl-1 and other anti-apoptotic proteins that belong to Bcl2 family. This evidence concerns the gene MCL1 and acute myeloid leukemia.