Levels of pro-apoptotic proteins did not change in any IRS2−/− group regardless of diabetes: BAD (ND: 101%; D: 99% of WT values), truncated BID (t-BID)/BID (ND: 96%; D: 101% of WT values) and BIM (ND: 96%; D: 112% of WT values; Fig. 3C,D and E, respectively). The gene discussed is BCL2L11; the disease is diabetes mellitus.