To test the hypothesis that higher levels of multiple CAMs reflect greater endothelial dysfunction and portend higher risk for T2D than an individual CAM we created an endothelial dysfunction index adding the quartiles of E-selectin and ICAM-1 with a possible rank sum of 2–8, the sum of two representing being in both the lowest quartile of each CAM and eight representing being in the highest quartile of each. This evidence concerns the gene ICAM1 and endothelial dysfunction.