Ay et al. [40] found that high expression of ORAI3 promoted non-small cell lung adenocarcinoma cell proliferation via the phosphoinositide 3-OH kinase (PI3K)/Akt signaling pathway, which was constitutively activated in lung cancer cells and was central to cell proliferation and survival. The gene discussed is ORAI3; the disease is non-small cell lung adenocarcinoma.