As shown in Fig. 8d, the number of CD31-positive microvessels (MVD/fields) was significantly reduced from 42.7 ± 3.5 to 17.3 ± 2.1 by treatment with honokiol (p < 0.01), indicating that honokiol may inhibit neovascularization within tumor tissues of the SAS SP xenograft. The gene discussed is PECAM1; the disease is neoplasm.