While studying the function of the miR-146 family, we noticed that both, miR-146a-5p and miR-146b-5p, putatively regulate the expression of RARB. We hypothesized that the loss of the expression of RARB in thyroid cancer tissue might be a result of the up-regulation of the miR-146a family, and the inhibition of these miRs might lead to the restoration of RARβ and increased effectiveness of retinoic acid adjuvant therapy. The gene discussed is RARB; the disease is thyroid cancer.