OCRL and oculocerebrorenal syndrome: It is questionable, however, whether this mechanism does explain the phenotypic differences between patients with Dent-2 disease and those with Lowe syndrome as Montjean et al. observed identical expression not only of OCRL but also of INPP5B at the RNA and protein levels in fibroblasts from both Dent-2 and Lowe syndrome patients [86].