Indeed, double knock-out of inpp5b and ocrl resulted in embryonic lethality, while double knock-out with expression of human INPP5B in mice using a bacterial artificial chromosome created a phenotype resembling Lowe syndrome/Dent-2 disease (postnatal growth failure, LMW proteinuria, and aminoaciduria) [96]. Here, OCRL is linked to oculocerebrorenal syndrome.