IRS1 and gastric cancer: In addition, He et al. [35] found that the resistance to CDDP was not only related to the miR-497 action on BCL2 mRNA, but also the action of miR-497 on IGF1R and IRS1 mRNAs in SGC7901/CDDP cells, suggesting this miRNA could modulate CDDP resistance of GC cells in part by targeting the IGF1R/IRS1 pathway [35].