Taken together, these data indicate that the miR-200bc/429 cluster and miR-181b could play a role in the development of multidrug resistance in GC cell lines, at least in part, through the modulation of apoptosis by targeting BCL2 and XIAP in the case of miR-200bc/429 cluster or targeting only BCL2 in the case of miR-181b and miR-497. This evidence concerns the gene BCL2 and gastric cancer.