A recent report investigating the potential role of Nodal, Cripto-1 and Notch4 in adult melanocytic lesions of the skin showed that significantly high levels of Nodal were detected in dysplastic nevi excised from adult patients who subsequently developed melanoma, compared to the control group of dysplastic nevi excised from adult patients with no history of melanoma [12]. The gene discussed is NOTCH4; the disease is dysplastic nevus.