In this study, we systematically investigated the immunogenicity and cross-protection efficiency of OMPs purified from mutants, including ∆waaC12, ∆waaF15, ∆waaG42, ∆rfaH49, ∆waaI43, ∆waaJ44, ∆waaL46, ∆wbaP45 and ∆wzy-48, and discovered potential OMP vaccines to protect against homologous or heterologous serotype Salmonella infection. This evidence concerns the gene OMP and Salmonella Infections.