For example, miR-206 exhibited crucial tumor-suppressor roles in the progression of breast cancer by regulating cyclin-D2 expression.17 In addition, miR-720, which acts as a tumor suppressor by inhibiting cell migration and invasion, was found to be downregulated in primary breast carcinoma.18 The expression levels of miR-485 itself were also demonstrated by recent studies to be correlated with cancer risk and could serve as biomarkers for diagnosis of multiple types of cancers. Here, CCND2 is linked to breast cancer.