CCND2 and breast carcinoma: For example, miR-206 exhibited crucial tumor-suppressor roles in the progression of breast cancer by regulating cyclin-D2 expression.17 In addition, miR-720, which acts as a tumor suppressor by inhibiting cell migration and invasion, was found to be downregulated in primary breast carcinoma.18 The expression levels of miR-485 itself were also demonstrated by recent studies to be correlated with cancer risk and could serve as biomarkers for diagnosis of multiple types of cancers.