PPARGC1A and cancer: In this context, it is interesting to note that PGC-1α-mediated enhanced mitochondrial respiration and oxidative phosphorylation did not appear to impact upon glycolytic and anabolic rates, and did not affect cancer cell proliferation or the kinetics of primary tumor growth.6 Therefore, the roles of miR-485-3p and miR-485-5p in cancer cell growth and proliferation require further investigation.