The roles of RhoGAP proteins have been investigated in cancer development and progression.21, 22, 23, 24, 25 Involvement of ARHGAP10 in cancers has also been recently concerned.4, 14, 15 In the present study, we confirmed that ARHGAP10 was extremely downregulated in 75 ovarian cancer tissues, compared with paired normal tissues. This evidence concerns the gene ARHGAP10 and cancer.