Besides serving as a RhoGAP for Cdc42,3 RhoA and RhoC,4 ARHGAP10 can also interact with several proteins, including α-catenin,5 ARF1,3 FAK, PKC-ζ6 and β-arrestin 1,7 and thus is involved in various cell functions, such as cell junction formation,5 vesicular trafficking of Golgi membranes,3 cardiac stress,6 influenza virus replication8 and stress fiber formation.7 Recently, methylation and single nucleotide polymorphisms of ARHGAP10 have been described in pediatric leukemia9 and invasive breast cancer,10 respectively, which indicated the association of ARHGAP10 and cancer. This evidence concerns the gene ARHGAP10 and cancer.