PARP1 and ovarian cancer: When DNA damage in proliferating cells are not repaired because of inadequate expression of a DNA repair gene, the risk of cancer is increased.27 Here, ARHGAP10 overexpression remarkably decreased cell cycle (PCNA28, 29 and PLK130, 31), DNA replication (MCM232, 33 and MCM334, 35) and BER pathway (PARP1 and PARP236, 37)-related factors, which may account for its suppression effects on the tumorigenicity of ovarian cancer.