Numerous studies have demonstrated that p27, CCND1 and caspase-9 are critical regulators downstream of the PTEN/AKT pathway that are responsible for cell-cycle progression and survival, respectively.57,58,59 In this study, we found that p27 and C-caspase-9 were notably upregulated and CCND1 was significantly downregulated in BRD7-overexpressing NPC cells, while the expression changes were the opposite when the miR-141 level was restored in BRD7-overexpressing NPC cells in vitro and in vivo. The gene discussed is CCND1; the disease is nasopharyngeal carcinoma.