CCND1 and neoplasm: Furthermore, IHC staining of tumor sections of xenografts demonstrated that p27 and c-PARP were decreased, while CCND1 was increased in 5-8F/BRD7 tumors when miR-141 expression was restored compared with the miR-NC-transfected 5-8F/BRD7 tumors (Figure 7c).