SCN4A and acute myeloid leukemia: Firstly, the repressive mark H3K9Me3 was enriched (~10-30fold) and significantly enhanced (~3-4fold) by GATA-1 overexpression, and also overlapped with GATA-1 occupancy (see Fig 4upper panels and S7B Fig) at the URE, the -13.4E and near the PP in the AML-ELs, whereas this was not observed in the SKM1 or HeLa cells (S7A Fig).