Unlike with GATA-1, we have not detected any PU.1 signal in the same precipitates suggesting that GATA-1, but not PU.1, can recruit DNMT1 in AML-EL (S9 Fig) and that GATA-1, rather than PU.1, is recruiting DNMT1 to the PU.1-bound-URE. The gene discussed is SPI1; the disease is acute myeloid leukemia.