Using this approach, cadherin-5 (CDH5) emerged as a novel biomarker for metastatic breast cancer (Fry et al, 2013), when assessed by ELISAs that incorporate measurements of glycosylation status, evaluated by binding of the lectin Helix pomatia agglutinin (HPA) known to detect poor prognosis metastatic cancer (Schumacher and Adam, 1997; Mitchell and Schumacher, 1999; Dwek et al, 2001). The gene discussed is CDH5; the disease is metastatic malignant neoplasm.