Several genes on this list (ARHGEF10, ADAP1, RAP1GAP) have a role in intracellular trafficking [19, 32, 33], and we also noted significant changes in ZEB2 and PRICKLE4. Notably, we previously reported that mutations in ZEB2 are associated with BA, and that morpholino-mediated knockdown of zeb2 or prickle1 leads to defects in biliary development [19, 32, 33]. This evidence concerns the gene RAP1GAP and breast angiosarcoma.