A similar dual regulation is possible for other pathways in BA, as there are reports of Hedgehog signaling being linked to IFNγ [43, 44], Hedgehog and Jagged/Notch working together [45], Jagged/Notch working with TGFβ and SMADs [46], and GLI2 working in the TGFβ pathway [47, 48]. The gene discussed is IFNG; the disease is breast angiosarcoma.