PRKAA2 and neoplasm: In marked contrast to our earlier findings [33], iGluAMPKdKO mice showed no signs of tumour development or premature death, suggesting that members of the AMPK-related kinase (AMPK-RK) family [32], rather than canonical AMPK α1 or α2-containing complexes, are responsible for the suppression of polyposis from proglucagon-expressing cells [37].